Title:

HIV-1 Protease Complexed With A Tripeptide Inhibitor

Compound:

Mol_Id: 1; Molecule: HIV-1 Protease; Chain: A, B; Ec: 3.4.23.16; Engineered: Yes; Mutation: Q7K, L33I, L63I; Biological_Unit: Dimer
Mol_Id: 2; Molecule: Tripeptide Glu-Asp-Leu; Chain: C; Engineered: Yes

Authors:

J. M. Louis, F. Dyda, N. T. Nashed, A. R. Kimmel, D. R. Davies

Exp. Method:

X-ray Diffraction

Classification:

Complex (Aspartic Protease/Inhibitor)

EC Number:

3.4.23.16 (HIV-1 retropepsin)

Source:

Human immunodeficiency virus type 1

Primary Citation:

Louis, J. M., Dyda, F., Nashed, N. T., Kimmel, A. R., Davies, D. R.: Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease. Biochemistry 37 pp. 2105 (1998)

Deposition Date:

27-Jan-1998

Release Date:

29-Apr-1998

Resolution [Å]:

2.00

R-Value:

0.189

Space Group:

P 2₁ 2₁ 2

Unit Cell:

dim [Å]:	a	58.47	b	86.44	c	45.81
angles [°]:	alpha	90.00	beta	90.00	gamma	90.00

Polymer Chains:

A, B, C

Residues:

201

Atoms:

1752

CATH:

Structural Classification

PDBSum:

Summary of PDB Structure

SCOP:

Structural Classification